反应详情

A solution of the product from the Example 34G, 2-(4-((1S,2S)-2-(((S)-2-methylpyrrolidin-1-yl)methyl)cyclopropyl)phenyl)pyridazin-3(2H)-one, (615 mg, 0.5 mmol) in methanol (10 mL) was treated with D-tartaric acid (350 mg) and stirred at ambient temperature for 30 minutes. The mixture was concentrated under the reduced pressure and the residue was crystallized in 2-propanol/acetone to provide the title product as white crystalline solid. M.P. 145-147.1° C. Anal. Calc. for C23H26N2.C4H6O6: C, 60.12; H, 6.36; N, 9.14. Found: C, 59.94; H, 6.57; N, 9.17.

1. concentrationThe mixture was concentrated under the reduced pressure
2. customthe residue was crystallized in 2-propanol/acetone