反应详情

5-ethenyl-4-methyl-2-benzofuran-1(3H)-one (1.5 g, 8.4 mmol) was added to DCM (25 mL) at 0° C. then meta-chloroperbenzoic acid (2.9 g, 17 mmol) was added and the mixture was stirred at room temperature overnight. The reaction mixture was washed once each with saturated aqueous Na2S2O3, saturated sodium bicarbonate, and brine. The organic layer was dried over Na2SO4, filtered, and evaporated to dryness. The crude material was purified by MPLC chromatography (eluting with 0-80% EtOAc/hexane solvent system) to yield 4-methyl-5-oxiran-2-yl-2-benzofuran-1(3H)-one.

1. washThe reaction mixture was washed once each with saturated aqueous Na2S2O3, saturated sodium bicarbonate, and brine
2. dry with materialThe organic layer was dried over Na2SO4
3. filtrationfiltered
4. customevaporated to dryness
5. customThe crude material was purified by MPLC chromatography (eluting with 0-80% EtOAc/hexane solvent system)