HRID515129

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12582612

8-Chloro[1,2,4]triazolo[4,3-a]pyrazine

C5H3ClN4

结构：Cc1c([C@@H](O)CN2CCC(CN)(c3ccccc3)C2)ccc2c1COC2=O.Cl

HCID90190517

未命名化合物

2 次

PRODUCTS

生成物

结构：Cc1c([C@@H](O)CN2CCC(CNc3nccn4cnnc34)(c3ccccc3)C2)ccc2c1COC2=O

HCID71566025

未命名化合物

PROCEDURE

实验过程

5-((1R)-2-(3-(([1,2,4]Triazolo[4,3-a]pyrazin-8-ylamino)methyl)-3-phenylpyrrolidin-1-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1(3H)-one was prepared in a similar fashion to that described for the synthesis of EXAMPLE 18 starting from 5-[(R)-2-[3-(Aminomethyl)-3-phenylpyrrolidin-1-yl]-1-hydroxyethyl}-4-methyl-2-benzofuran-1(3H)-one hydrochloride [INTERMEDIATE 15] and 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine.