HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Chloro-(1,2,4)triazolo(4,3-a)pyrazine → 5-((1R)-2-(3-(([1,2,4]Triazolo[4,3-a]pyrazin-8-ylamino)methyl)-3-phenylpyrrolidin-1-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Chloro-(1,2,4)triazolo(4,3-a)pyrazine | HCID 12582612 | — |
| Reactant | 5-((1R)-2-(3-(aminomethyl)-3-phenylpyrrolidin-1-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1(3H)-one hydrochloride | HCID 90190517 | — |
| Product | 5-((1R)-2-(3-(([1,2,4]Triazolo[4,3-a]pyrazin-8-ylamino)methyl)-3-phenylpyrrolidin-1-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1(3H)-one | HCID 71566025 | — |
Reaction Steps
5-((1R)-2-(3-(([1,2,4]Triazolo[4,3-a]pyrazin-8-ylamino)methyl)-3-phenylpyrrolidin-1-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1(3H)-one was prepared in a similar fashion to that described for the synthesis of EXAMPLE 18 starting from 5-[(R)-2-[3-(Aminomethyl)-3-phenylpyrrolidin-1-yl]-1-hydroxyethyl}-4-methyl-2-benzofuran-1(3H)-one hydrochloride [INTERMEDIATE 15] and 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108947B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-3d31b26159ff4db892208a5ca5d12b26 |
| Source note | uspto-grants-2015_08 |