Hydrochloric Acid → HCID 55283766, compound

Participants

Reaction Steps

To a stirred solution of N-[(3R)-3-hydroxy-4,4-dimethyl-pentyl]-carbamic acid tert-butyl ester (1.2 g, 5.19 mmol) in dioxane (5 ml) is added 4N hydrochloric acid in dioxane (12 ml) at 0° C. and the mixture is stirred for 1 h at room temperature. The reaction mixture is concentrated in vacuo and solid is triturated with pentane yielding (3R)-1-amino-4,4-dimethyl-pentan-3-ol (0.5 g, 2.98 mmol, 57%).

Provenance & Evidence