Hydrochloric Acid → HCID 55283766, compound

HRID 515184Notes

Reaction equation

HRID 515184 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C@@H:10]([OH:15])[C:11]([CH3:14])([CH3:13])[CH3:12])(C)(C)C.Cl>O1CCOCC1>[NH2:7][CH2:8][CH2:9][C@@H:10]([OH:15])[C:11]([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86699751HCID 86699751, compound

Product 1

HCID 55283766HCID 55283766, compoundYield 57.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of N-[(3R)-3-hydroxy-4,4-dimethyl-pentyl]-carbamic acid tert-butyl ester (1.2 g, 5.19 mmol) in dioxane (5 ml) is added 4N hydrochloric acid in dioxane (12 ml) at 0° C. and the mixture is stirred for 1 h at room temperature. The reaction mixture is concentrated in vacuo and solid is triturated with pentane yielding (3R)-1-amino-4,4-dimethyl-pentan-3-ol (0.5 g, 2.98 mmol, 57%).

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo and solid
  2. customis triturated with pentane

Sources & evidence

ORD record
ord-1afb6ab28a1549db89a8f00adf286590
Source dataset
uspto-grants-2015_08
Patent number
US09108936B2

Reaction notes

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