2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol → Isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

HRID 515247Notes

Reaction equation

HRID 515247 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8])=[CH:5][N:6]=1.Cl[C:14]1[N:19]=[C:18]([CH3:20])[N:17]=[C:16]([N:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][OH:29])[CH2:23][CH2:22]2)[CH:15]=1>>[OH:29][CH2:28][CH2:27][N:24]1[CH2:23][CH2:22][N:21]([C:16]2[N:17]=[C:18]([CH3:20])[N:19]=[C:14]([NH:1][C:2]3[S:3][C:4]([C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8])=[CH:5][N:6]=3)[CH:15]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 144795582-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanolHCID 86676429Isopropyl 2-aminothiazole-5-formate

Product 1

HCID 49822135Isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formateYield 65.2%

Procedure

Prepared from isopropyl 2-aminothiazole-5-formate and Compound 4: isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate was obtained (yield: 65.2%).

Sources & evidence

ORD record
ord-fb313e5ebe7040c4831a9caeebc48b67
Source dataset
uspto-grants-2015_08
Patent number
US09108954B2

Reaction notes

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