HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol → Isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol | HCID 14479558 | — |
| Reactant | Isopropyl 2-aminothiazole-5-formate | HCID 86676429 | — |
| Product | Isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate | HCID 49822135 | 65.2% |
Reaction Steps
Prepared from isopropyl 2-aminothiazole-5-formate and Compound 4: isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate was obtained (yield: 65.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108954B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-fb313e5ebe7040c4831a9caeebc48b67 |
| Source note | uspto-grants-2015_08 |