Ethyl 2-chloro-1,3-thiazole-5-carboxylate → Ethyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate

HRID 515251Notes

Reaction equation

HRID 515251 reaction equation
Cl[C:2]1[S:3][C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:6]=1.[NH2:12][C:13]1[CH:18]=[C:17]([Br:19])[N:16]=[C:15]([CH3:20])[N:14]=1>>[Br:19][C:17]1[N:16]=[C:15]([CH3:20])[N:14]=[C:13]([NH:12][C:2]2[S:3][C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:6]=2)[CH:18]=1

Participants

3

Reactant 2

HCID 19017727Ethyl 2-chloro-1,3-thiazole-5-carboxylateHCID 569657194-Amino-6-bromo-2-methylpyrimidine

Product 1

HCID 49821807Ethyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formateYield 75.5%

Procedure

Prepared from ethyl 2-chlorothiazole-5-formate and Compound 9: ethyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate was yielded (yield: 75.5%).

Sources & evidence

ORD record
ord-11832d28fa804ee8b6b4032b40e5a2e9
Source dataset
uspto-grants-2015_08
Patent number
US09108954B2

Reaction notes

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