1-(2-Hydroxyethyl)piperazine → Ethyl (6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

HRID 515254Notes

Reaction equation

HRID 515254 reaction equation
Br[C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]2[S:11][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][N:14]=2)[CH:3]=1.[OH:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[OH:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][N:26]([C:2]2[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]3[S:11][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][N:14]=3)[CH:3]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 49821807Ethyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Product 1

HCID 49821971Ethyl (6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formateYield 80.6%

Procedure

Prepared from ethyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate and Compound 3: ethyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate was yielded (yield: 80.6%).

Sources & evidence

ORD record
ord-2ce6adc46a6748cbbc1126f3ba3feee5
Source dataset
uspto-grants-2015_08
Patent number
US09108954B2

Reaction notes

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