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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 515254Generated: October 30, 2026

1-(2-Hydroxyethyl)piperazine → Ethyl (6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

https://huagongshe.com/reaction/515254

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Hydroxyethyl)piperazineHCID 7677—
ReactantEthyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formateHCID 49821807—
ProductEthyl (6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formateHCID 4982197180.6%

Reaction Steps

Prepared from ethyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate and Compound 3: ethyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate was yielded (yield: 80.6%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09108954B2
Source datasetuspto-grants-2015_08
ORD IDord-2ce6adc46a6748cbbc1126f3ba3feee5
Source noteuspto-grants-2015_08