HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Hydroxyethyl)piperazine → Dasatinib
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(6-bromo-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-formamide | HCID 86676430 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Dasatinib | HCID 3062316 | — |
Reaction Steps
1-(2-hydroxyethyl)piperazine (Compound 3) (65 g, 0.5 mol), 2-(6-bromo-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-formamide (Compound 14) (43.9 g, 0.1 mol), isopropanol (650 mL) and DIPEA (28.3 g, 0.2 mol) were mixed in reaction flask and reacted by refluxing for 5 h. It was condensed by vacuum to dry to give crude Dasatinib (Compound 1) (purity: 95.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108954B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-ecdb772021574916900d608cab219430 |
| Source note | uspto-grants-2015_08 |