反应详情

1-(2-hydroxyethyl)piperazine (Compound 3) (65 g, 0.5 mol), 2-(6-bromo-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-formamide (Compound 14) (43.9 g, 0.1 mol), isopropanol (650 mL) and DIPEA (28.3 g, 0.2 mol) were mixed in reaction flask and reacted by refluxing for 5 h. It was condensed by vacuum to dry to give crude Dasatinib (Compound 1) (purity: 95.4%).

1. customreacted
2. temperatureby refluxing for 5 h
3. customcondensed by vacuum
4. customto dry