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Potassium Carbonate → 1,1,1,3,3,3-Hexafluoro-2-(4-((4-(4-nitrophenoxy)piperidin-1-yl)methyl)phenyl)propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-(4-Nitrophenoxy)piperidine | HCID 21918653 | — |
| 反応物 | 2-[4-(Bromomethyl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol | HCID 23527396 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1,1,1,3,3,3-Hexafluoro-2-(4-((4-(4-nitrophenoxy)piperidin-1-yl)methyl)phenyl)propan-2-ol | HCID 86670925 | — |
反応手順
4-(4-Nitrophenoxy)piperidine (2.70 mmol, 600 mg), 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (2.70 mmol, 910 mg) and potassium carbonate (5.40 mmol, 746 mg) were combined and stirred at 70° C. in acetonitrile (20 mL) overnight. The reaction mixture was filtered and the filtrate concentrated under vacuum to afford the title compound. MS (ESI) m/z 490.0 [M+H]+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09108939B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-ac89dcbe8e564db8a454abe2715aa522 |
| 出典メモ | uspto-grants-2015_08 |