Trifluoroacetic acid → 1-(Cyclopropylmethyl)-3-(4-(piperidin-4-yloxy)phenyl)urea

Participants

Reaction Steps

To a stirring solution of tert-butyl 4-(4-(3-(cyclopropylmethyl)ureido)phenoxy)piperidine-1-carboxylate (2.57 mmol, 1 g) in dichloromethane (10 mL) was added trifluoroacetic acid (2 mL). The resulting solution was stirred at room temperature for 30 minutes then was concentrated under vacuum. The residue was dissolved in dichloromethane and purified by SCX chromatography to give the title compound (350 mg). MS (ESI) m/z 290.1 [M+H]+

Provenance & Evidence