反应详情

To a stirring solution of tert-butyl 4-(4-(3-(cyclopropylmethyl)ureido)phenoxy)piperidine-1-carboxylate (2.57 mmol, 1 g) in dichloromethane (10 mL) was added trifluoroacetic acid (2 mL). The resulting solution was stirred at room temperature for 30 minutes then was concentrated under vacuum. The residue was dissolved in dichloromethane and purified by SCX chromatography to give the title compound (350 mg). MS (ESI) m/z 290.1 [M+H]+

1. concentrationthen was concentrated under vacuum
2. dissolutionThe residue was dissolved in dichloromethane
3. custompurified by SCX chromatography