反应详情

tert-Butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate (2.272 mmol, 960 mg) was dissolved in dichloromethane (40 mL) and trifluoroacetic acid (45.4 mmol, 5181 mg) added. The mixture was stirred at room temperature for 3 hours before concentrating under reduced pressure. The resulting residue was purified by strong cation exchange column chromatography to afford the title compound (110 mg). MS (ESI) m/z 323.5 [M+H]+

1. concentrationbefore concentrating under reduced pressure
2. customThe resulting residue was purified by strong cation exchange column chromatography