Trifluoroacetic acid → HCID 61684683, compound

HRID 515317Notes

Reaction equation

HRID 515317 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[NH:12]1[CH2:11][CH2:10][CH:9]([S:8][C:5]2[CH:6]=[CH:7][C:2]([NH2:1])=[CH:3][CH:4]=2)[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18538812Tert-butyl 4-(4-aminophenylthio)piperidine-1-carboxylate

Product 1

HCID 61684683HCID 61684683, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(4-aminophenylthio)piperidine-1-carboxylate (9.27 mmol, 2.859 g) was dissolved in dichloromethane (10 ml) and trifluoroacetic acid (10 mL) and the reaction mixture stirred at room temperature for 30 minutes. The reaction mixture was purified via SCX column chromatography to afford the title compound (1.39 g).

Workup

  1. customThe reaction mixture was purified via SCX column chromatography

Sources & evidence

ORD record
ord-e56cebc3698644ac9c0709153577fa9b
Source dataset
uspto-grants-2015_08
Patent number
US09108939B2

Reaction notes

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