反应详情

A mixture of tert-butyl ethyl(piperidin-4-yl)carbamate (10.95 mmol, 2.5 g), 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (10.95 mmol, 3.69 g) and sodium hydrogencarbonate (16.42 mmol, 1.380 g) in acetonitrile (40 ml) was refluxed for 2 hours. The reaction was concentrated under reduced pressure and dichloromethane was added. The suspension was filtered and the filtrate was chromatographed on silica (eluting with a gradient of dichloromethane to ethyl acetate) to give the title compound (3.3 g). MS (ESI) m/z 485.1 [M+H]+

1. temperaturewas refluxed for 2 hours
2. concentrationThe reaction was concentrated under reduced pressure and dichloromethane
3. additionwas added
4. filtrationThe suspension was filtered
5. customthe filtrate was chromatographed on silica (
6. washeluting with a gradient of dichloromethane to ethyl acetate)