Trifluoroacetic acid → HCID 67193440, compound

HRID 515366Notes

Reaction equation

HRID 515366 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[CH:8][N:7]([CH:10]3[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)[C:6]=2[CH:23]=1.FC(F)(F)C(O)=O>ClCCl>[NH:13]1[CH2:12][CH2:11][CH:10]([N:7]2[C:6]3[CH:23]=[C:2]([NH2:1])[CH:3]=[CH:4][C:5]=3[N:9]=[CH:8]2)[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86670992HCID 86670992, compound

Product 1

HCID 67193440HCID 67193440, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(6-amino-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate (5.69 mmol, 1.799 g) was stirred in dichloromethane (5 mL)/trifluoroacetic acid (5 mL) for 1 hour at room temperature. The reaction was concentrated at reduced pressure and passed down an SCX column to afford the title compound (1.01 g). MS (ESI) m/z 217.1 [M+H]+

Workup

  1. concentrationThe reaction was concentrated at reduced pressure

Sources & evidence

ORD record
ord-6215e80efadd44cd9482f9f0d88106b7
Source dataset
uspto-grants-2015_08
Patent number
US09108939B2

Reaction notes

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