Trifluoroacetic acid → HCID 67192041, compound

HRID 515369Notes

Reaction equation

HRID 515369 reaction equation
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]([CH:9]3[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]3)[CH:7]=[N:8][C:4]=2[CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[NH:12]1[CH2:11][CH2:10][CH:9]([N:6]2[C:5]3[CH:22]=[CH:23][C:2]([NH2:1])=[CH:3][C:4]=3[N:8]=[CH:7]2)[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68272180HCID 68272180, compound

Product 1

HCID 67192041HCID 67192041, compoundYield 128.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(5-amino-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate (3.75 mmol, 1.187 g) was stirred in dichloromethane (5 mL)/trifluoroacetic acid (5 mL) for 1 hour at room temperature. The reaction was concentrated under vacuum and passed down an SCX column to afford the title compound (1.042 g). MS (ESI) m/z 217.1 [M+H]+

Workup

  1. concentrationThe reaction was concentrated under vacuum

Sources & evidence

ORD record
ord-87a20190e6434235989c6b91ceebdd55
Source dataset
uspto-grants-2015_08
Patent number
US09108939B2

Reaction notes

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