反应详情

1-(Piperidin-4-yl)-1H-indazol-6-amine (3.33 mmol, 0.721 g), 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (3.33 mmol, 1.124 g) and potassium carbonate (6.67 mmol, 0.921 g) were combined and stirred overnight at room temperature in acetonitrile (15 mL). The reaction mixture was concentrated at reduced pressure and the resulting residue taken up in dichloromethane. The organic phase was washed with water and dried over sodium sulfate. The solvent was removed and the resulting residue was purified by silica chromatography (eluting with a solvent gradient from dichloromethane to 8% methanol/dichloromethane) to afford the title compound (664 mg). MS (ESI) m/z 473.5 [M+H]+

1. concentrationThe reaction mixture was concentrated at reduced pressure
2. washThe organic phase was washed with water
3. dry with materialdried over sodium sulfate
4. customThe solvent was removed
5. customthe resulting residue was purified by silica chromatography (
6. washeluting with a solvent gradient from dichloromethane to 8% methanol/dichloromethane)