4-Benzyl-5-phenyl-1,4-oxazepane → 5-Phenyl-1,4-oxazepane hydrochloride

HRID 515449Notes

Reaction equation

HRID 515449 reaction equation
[ClH:1].CC1CCOCCN1.C([N:17]1[CH:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)C1C=CC=CC=1>>[ClH:1].[C:24]1([CH:23]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18][NH:17]2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 667185434-Benzyl-5-phenyl-1,4-oxazepaneHCID 667186395-Methyl-1,4-oxazepane hydrochloride

Product 1

HCID 667185105-Phenyl-1,4-oxazepane hydrochloride

Procedure

5-Phenyl-[1,4]oxazepane hydrochloride was prepared by the same procedure as that of 5-methyl-[1,4]oxazepane hydrochloride except for utilizing 4-benzyl-5-phenyl-[1,4]oxazepane instead of 4-benzyl-5-methyl-[1,4]oxazepane. Then 5-phenyl-[1,4]oxazepane hydrochloride was obtained as white solid (0.14 g, 0.65 mmol, 73%).

Sources & evidence

ORD record
ord-c80cd0e3a3274aaf81da6b56f42ac077
Source dataset
uspto-grants-2015_08
Patent number
US09108957B2

Reaction notes

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