反应详情

To a solution of (S)-6-(4-bromophenyl)-4-((R)-1-phenylethyl)-[1,4]oxazepane (0.610 g, 1.69 mmol) in 1,2-dichloroethane (2.83 ml) was added 1-chloroethyl chloroformate (0.605 g, 4.23 mmol) at room temperature. The mixture was refluxed for 4 hours and cooled to room temperature. After addition of methanol (5.0 ml), the mixture was refluxed for 3 hours and concentrated under reduced pressure to afford the crude product. This crude product was washed with ether, dried under reduced pressure to afford (S)-6-(4-bromophenyl)-1,4-oxazepane hydrochloride as white solid (0.424 g, 86%).

1. temperatureThe mixture was refluxed for 4 hours
2. temperaturethe mixture was refluxed for 3 hours
3. concentrationconcentrated under reduced pressure
4. customto afford the crude product
5. washThis crude product was washed with ether
6. customdried under reduced pressure