4-Benzyl-6-(4-[1,2,4]oxadiazol-3-yl-phenyl)-[1,4]oxazepane → 6-(4-[1,2,4]Oxadiazol-3-yl-phenyl)-[1,4]oxazepane hydrochloride

HRID 515472Notes

Reaction equation

HRID 515472 reaction equation
[O:1]1[CH:5]=[N:4][C:3]([C:6]2[CH:11]=[CH:10][C:9]([CH:12]3[CH2:18][O:17][CH2:16][CH2:15][NH:14][CH2:13]3)=[CH:8][CH:7]=2)=[N:2]1.[ClH:19].CC1CCOCCN1.C(N1CC(C2C=CC(C3N=CON=3)=CC=2)COCC1)C1C=CC=CC=1>>[ClH:19].[O:1]1[CH:5]=[N:4][C:3]([C:6]2[CH:7]=[CH:8][C:9]([CH:12]3[CH2:18][O:17][CH2:16][CH2:15][NH:14][CH2:13]3)=[CH:10][CH:11]=2)=[N:2]1

Participants

4

Reactant 3

HCID 667185554-Benzyl-6-(4-[1,2,4]oxadiazol-3-yl-phenyl)-[1,4]oxazepaneHCID 667186395-Methyl-1,4-oxazepane hydrochlorideHCID 672822096-(4-[1,2,4]Oxadiazol-3-yl-phenyl)-[1,4]oxazepane

Product 1

HCID 672822086-(4-[1,2,4]Oxadiazol-3-yl-phenyl)-[1,4]oxazepane hydrochloride

Procedure

Preparation of 6-(4-[1,2,4]oxadiazol-3-yl-phenyl) -[1,4]oxazepane was performed by the same procedure as that of 5-methyl-[1,4]oxazepane hydrochloride except for utilizing 4-benzyl-6-(4-[1,2,4]oxadiazol-3-yl-phenyl)-[1,4]oxazepane instead of 4-benzyl-5-methyl-[1,4]oxazepane. 6-(4-[1,2,4]Oxadiazol-3-yl-phenyl)-[1,4]oxazepane hydrochloride was obtained as white solid (0.13 g, 0.45 mmol, 86%).

Sources & evidence

ORD record
ord-67d329b3dac04e5ea3c5226484f49acc
Source dataset
uspto-grants-2015_08
Patent number
US09108957B2

Reaction notes

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