7-[4-(5-Methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-[1,4]oxazepane hydrochloride → 6-(4-[1,2,4]Oxadiazol-5-yl-phenyl)-[1,4]oxazepane hydrochloride

HRID 515475Notes

Reaction equation

HRID 515475 reaction equation
[ClH:1].CC1ON=C(C2C=CC(C3OCCNCC3)=CC=2)N=1.C([N:28]1[CH2:34][CH:33]([C:35]2[CH:40]=[CH:39][C:38]([C:41]3[O:45][N:44]=[CH:43][N:42]=3)=[CH:37][CH:36]=2)[CH2:32][O:31][CH2:30][CH2:29]1)C1C=CC=CC=1>>[ClH:1].[O:45]1[C:41]([C:38]2[CH:39]=[CH:40][C:35]([CH:33]3[CH2:32][O:31][CH2:30][CH2:29][NH:28][CH2:34]3)=[CH:36][CH:37]=2)=[N:42][CH:43]=[N:44]1

Participants

3

Reactant 2

HCID 667185737-[4-(5-Methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-[1,4]oxazepane hydrochlorideHCID 667185954-Benzyl-6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-[1,4]oxazepane

Product 1

HCID 672830996-(4-[1,2,4]Oxadiazol-5-yl-phenyl)-[1,4]oxazepane hydrochloride

Procedure

6-(4-[1,2,4]Oxadiazol-5-yl-phenyl)-[1,4]oxazepane hydrochloride was prepared by the same procedure as that of 7-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-[1,4]oxazepane hydrochloride except for utilizing 4-benzyl-6-(4-[1,2,4]oxadiazol-5-yl-phenyl)-[1,4]oxazepane instead of 7-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-4-(1-phenyl-ethyl)-[1,4]oxazepane 6-(4-[1,2,4]Oxadiazol-5-yl-phenyl)-[1,4]oxazepane hydrochloride was obtained as white solid (0.03 g, 0.09 mmol, 90%).

Sources & evidence

ORD record
ord-27494ee2cff64f5081bfc36464a272c5
Source dataset
uspto-grants-2015_08
Patent number
US09108957B2

Reaction notes

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