Hydrochloric Acid → 7-(2-Cyano-benzyl)-xanthine

HRID 515515Notes

Reaction equation

HRID 515515 reaction equation
N[C:2]1[NH:3][C:4](=[O:20])[C:5]2[N:6]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[C:18]#[N:19])[CH:7]=[N:8][C:9]=2[N:10]=1.N([O-])=[O:22].[Na+].O.Cl>C(O)(=O)C>[C:18]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][N:6]1[C:5]2[C:4](=[O:20])[NH:3][C:2](=[O:22])[NH:10][C:9]=2[N:8]=[CH:7]1)#[N:19]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 23668193Sodium NitriteHCID 1360655872-Amino-7-(2-cyano-benzyl)-1,7-dihydro-purin-6-one

Product 1

HCID 575194237-(2-Cyano-benzyl)-xanthine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Prepared by treating 16.68 g of 2-amino-7-(2-cyano-benzyl)-1,7-dihydro-purin-6-one with 17.00 g of sodium nitrite in a mixture of 375 ml of conc. acetic acid, 84 ml of water and 5.2 ml of conc. hydrochloric acid at 50° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-376d1d1c1ae94d0c8a981f410f9103a7
Source dataset
uspto-grants-2015_08
Patent number
US09108964B2

Reaction notes

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