Potassium tert-butoxide → HCID 66754625, compound

HRID 515527Notes

Reaction equation

HRID 515527 reaction equation
Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]([C:13]([F:16])([F:15])[F:14])[N:4]=1.CC(C)([O-])C.[K+]>O1CCCC1>[CH3:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5]([C:13]([F:15])([F:14])[F:16])[N:4]=1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 57514538HCID 57514538, compound

Product 1

HCID 66754625HCID 66754625, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by treating 905 mg of 1-chloromethyl-3-trifluoromethyl-3,4-dihydro-isoquinoline with 420 mg of potassium-tert. butoxide in 10 ml of tetrahydrofuran at ambient temperature.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e1e4979bb8d646c28135ef1b0fac0c7f
Source dataset
uspto-grants-2015_08
Patent number
US09108964B2

Reaction notes

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