Hydrochloric Acid → 1196155-85-7

Participants

Reaction Steps

Hydrogen chloride was passed through a mixture of toluene (485 mL), methanol (16.8 g, 0.112 mol) and 3,5-dichlorophenylacetonitrile (100 g, 0.107 mol) at 25° C. When the hydrogen chloride uptake ceased, the mixture was sparged with nitrogen for 30 min. The mixture was filtered and the collected solid washed with toluene (150 mL) and dried overnight in a vacuum oven (50° C. at 25 in. Hg) to yield an off-white solid (98.4 g, 72%).

Provenance & Evidence