Hydrochloric Acid → 1196155-85-7

HRID 515547Notes

Reaction equation

HRID 515547 reaction equation
Cl.[CH3:2][OH:3].[Cl:4][C:5]1[CH:6]=[C:7]([CH2:12][C:13]#[N:14])[CH:8]=[C:9]([Cl:11])[CH:10]=1>C1(C)C=CC=CC=1>[ClH:4].[Cl:4][C:5]1[CH:6]=[C:7]([CH2:12][C:13](=[NH:14])[O:3][CH3:2])[CH:8]=[C:9]([Cl:11])[CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 887MethanolHCID 126899782-(3,5-Dichlorophenyl)acetonitrile

Product 1

HCID 722112961196155-85-7Yield 722.6%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Hydrogen chloride was passed through a mixture of toluene (485 mL), methanol (16.8 g, 0.112 mol) and 3,5-dichlorophenylacetonitrile (100 g, 0.107 mol) at 25° C. When the hydrogen chloride uptake ceased, the mixture was sparged with nitrogen for 30 min. The mixture was filtered and the collected solid washed with toluene (150 mL) and dried overnight in a vacuum oven (50° C. at 25 in. Hg) to yield an off-white solid (98.4 g, 72%).

Workup

  1. customthe mixture was sparged with nitrogen for 30 min
  2. filtrationThe mixture was filtered
  3. washthe collected solid washed with toluene (150 mL)
  4. customdried overnight in a vacuum oven (50° C. at 25 in. Hg)

Sources & evidence

ORD record
ord-621db8db886745d297d2f1f3e87da9c6
Source dataset
uspto-grants-2015_08
Patent number
US09108965B2

Reaction notes

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