Water → Benzeneacetic acid, 3,5-dichloro-, methyl ester

HRID 515548Notes

Reaction equation

HRID 515548 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH2:10][C:11](=N)[O:12][CH3:13])[CH:6]=[C:7]([Cl:9])[CH:8]=1.C1(C)C=CC=CC=1.[OH2:22]>>[Cl:2][C:3]1[CH:4]=[C:5]([CH2:10][C:11]([O:12][CH3:13])=[O:22])[CH:6]=[C:7]([Cl:9])[CH:8]=1

Participants

4

Reactant 3

HCID 962WaterHCID 1140TolueneHCID 722112961196155-85-7

Product 1

HCID 67195643Benzeneacetic acid, 3,5-dichloro-, methyl esterYield 91%

Procedure

To methyl 3,5-dichlorobenzeneethanimidate hydrochloride (1:1) (i.e. the product from Step A1a) (50 g, 0.107 mol) was added to a mixture of toluene (167 mL) and water (167 mL). After 60 min the organic phase was removed, dried (MgSO4), and evaporated to give the title compound as an oil (39 g, 91%).

Workup

  1. customAfter 60 min the organic phase was removed
  2. dry with materialdried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-e6b80a59adf2446fb06a3f78c2275abc
Source dataset
uspto-grants-2015_08
Patent number
US09108965B2

Reaction notes

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