反应详情

温度

55 °C

Purified oxymorphone (17.8 g, 59 mmol) was suspended in 94% aq. ethanol (107 ml) and stirred at 50-60° C. Concentrated hydrochloric acid (32%) was added slowly to adjust the pH to 2.58. The mixture was allowed to cool to room temperature, and then cooled further to 0-10° C., stirred for 2 hours and filtered then washed with ethanol (3×20 ml). The isolated solids were dried at 75° C. under 25 inches-Hg overnight to give oxymorphone HCl as white solids (17.3 g, 51 mmol, 86.7% yield).

1. temperatureto cool to room temperature
2. temperaturecooled further to 0-10° C.
3. stirringstirred for 2 hours
4. filtrationfiltered
5. washthen washed with ethanol (3×20 ml)
6. customThe isolated solids were dried at 75° C. under 25 inches-Hg overnight