反应详情

温度

55 °C

To a solution of buprenorphine (5.1 g, 11 m mol) in ethanol (60 ml) at 50-60° C. is added concentrated hydrochloric acid to pH 2.5, the heating is maintained at 50-60° C. for 2 hours, and cooled to 10-15° C. The mixture is filtered to collect the solid. The solid is washed with cold ethanol and dried at 80° C. under 25 inch Hg of vacuum for 4 hours to give the final product (expected yield: 5.3 g; 96% Yield). This product is identical to a USP standard of Buprenorphine Hydrochloride.

1. temperaturecooled to 10-15° C
2. filtrationThe mixture is filtered
3. customto collect the solid
4. washThe solid is washed with cold ethanol
5. customdried at 80° C. under 25 inch Hg of vacuum for 4 hours