反应详情

温度

60 °C

Ethyl 2-(2-hydroxy-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate (0.100 g, 0.366 mmol), cesium carbonate (0.179 g, 0.549 mmol) and 4-(chloromethyl)-1,2-diethoxybenzene (0.118 g, 0.549 mmol) were taken up in DMA (2 mL) and heated to 60° C. for 16 h in a 20 mL sealed scintillation vial. The reaction was cooled down to room temperature and filtered by vacuum filtration through a glass fiber paper. The solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (0.103 g) as an off-white solid. LCMS m/z=452.3 [M+H]+.

1. customsealed scintillation vial
2. temperatureThe reaction was cooled down to room temperature
3. filtrationfiltered by vacuum filtration through a glass fiber paper
4. customThe solvent was removed under reduced pressure
5. customThe residue was purified by silica gel column chromatography