6-Chloro-N-((4-methoxyphenyl)methyl)-5-(trifluoromethyl)-3-pyridinamine → 3-(Trifluoromethyl)-[2,3'-bipyridin]-5-amine

HRID 515786Notes

Reaction equation

HRID 515786 reaction equation
ClC1N=CC(NCC2C=CC(OC)=CC=2)=CC=1C(F)(F)F.COC1C=CC(C[NH:29][C:30]2[CH:31]=[C:32]([C:42]([F:45])([F:44])[F:43])[C:33]([C:36]3[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=3)=[N:34][CH:35]=2)=CC=1>>[F:44][C:42]([F:43])([F:45])[C:32]1[C:33]([C:36]2[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=2)=[N:34][CH:35]=[C:30]([NH2:29])[CH:31]=1

Participants

3

Reactant 2

HCID 250200336-Chloro-N-((4-methoxyphenyl)methyl)-5-(trifluoromethyl)-3-pyridinamineHCID 67374880N-(4-methoxybenzyl)-3-(trifluoromethyl)-[2,3'-bipyridin]-5-amine

Product 1

HCID 673760113-(Trifluoromethyl)-[2,3'-bipyridin]-5-amine

Procedure

The title compound was synthesized as described for Intermediate 1, Step 5 using N-(4-methoxybenzyl)-3-(trifluoromethyl)-[2,3′-bipyridin]-5-amine as the starting material. 1H NMR (300 MHz, CDCl3) δ 8.71 (dd, 1H), 8.64 (dd, 1H), 8.30 (dd, 1H), 7.78 (m, 1H), 7.35 (m, 1H), 7.32 (d, 1H), 4.05 (s, 2H).

Sources & evidence

ORD record
ord-b21b5ff90fb040bd87acd34e3dfae670
Source dataset
uspto-grants-2015_08
Patent number
US09108944B2

Reaction notes

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