Hydrochloric Acid → HCID 117833902, compound

HRID 515889Notes

Reaction equation

HRID 515889 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7](=[O:26])[CH2:8][C@@H:9]2[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][N:10]2C(OC(C)(C)C)=O)[CH2:3][CH2:2]1.[ClH:27]>ClCCl.CCOCC>[ClH:27].[N:4]1([C:7](=[O:26])[CH2:8][C@@H:9]2[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][NH:10]2)[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131733309HCID 131733309, compound

Product 1

HCID 117833902HCID 117833902, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 2.88 g (7.18 mmol) of the compound obtained in Step A in 16 mL of dichloromethane, there are added dropwise 80 mL (80 mmol) of 1M solution of HCl in ether. The batch is stirred at ambient temperature for 15 hours, and then the suspension is filtered and the precipitate washed with ether. After drying, the title product is obtained in the form of a solid.

Workup

  1. filtrationthe suspension is filtered
  2. washthe precipitate washed with ether
  3. customAfter drying

Sources & evidence

ORD record
ord-0774e99448cb4e9cb1fe174d7a08193a
Source dataset
uspto-grants-2015_08
Patent number
US09108983B2

Reaction notes

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