Hydrochloric Acid → HCID 117831262, compound

HRID 515929Notes

Reaction equation

HRID 515929 reaction equation
[Si]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]([C:51]2[CH:55]=[C:54]([C:56]#[N:57])[N:53]([CH3:58])[C:52]=2[CH3:59])[C:16]([C:18]2[CH:22]=[C:21]([C:23]3[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:24]=3[C:30]([N:32]3[C@H:41]([CH2:42][N:43]4[CH2:48][CH2:47][O:46][CH2:45][CH2:44]4)[CH2:40][C:39]4[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=4)[CH2:33]3)=[O:31])[N:20]([CH3:49])[C:19]=2[CH3:50])=[O:17])=[CH:11][CH:10]=1)(C(C)(C)C)(C)C.Cl>CCOCC>[ClH:29].[Cl:29][C:27]1[CH:26]=[CH:25][C:24]([C:30]([N:32]2[C@H:41]([CH2:42][N:43]3[CH2:48][CH2:47][O:46][CH2:45][CH2:44]3)[CH2:40][C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH2:33]2)=[O:31])=[C:23]([C:21]2[N:20]([CH3:49])[C:19]([CH3:50])=[C:18]([C:16]([N:15]([C:51]3[CH:55]=[C:54]([C:56]#[N:57])[N:53]([CH3:58])[C:52]=3[CH3:59])[C:12]3[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=3)=[O:17])[CH:22]=2)[CH:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131733326HCID 131733326, compound

Product 1

HCID 117831262HCID 117831262, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The compound of Step A is deprotected in accordance with the protocol described in Step D of Example 1. The product thereby obtained is finally subjected to a step of conversion into salt form in the presence of HCl in ether. After filtration and lyophilisation in a mixture of acetonitrile/water, the expected product is obtained.

Workup

  1. customThe product thereby obtained
  2. filtrationAfter filtration and lyophilisation
  3. additionin a mixture of acetonitrile/water

Sources & evidence

ORD record
ord-b3f9affd34864d4593cccff1b9770a82
Source dataset
uspto-grants-2015_08
Patent number
US09108983B2

Reaction notes

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