反应详情

温度

100 °C

In a microwave vial, a solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1 g, 5.15 mmol) in DMF (10 mL) was added cesium carbonate (5.04 g, 15.46 mmol) and 2-iodopropane (2.58 mL, 25.8 mmol). The mixture was heated at 100° C. overnight. After cooling to RT, H2O (300 mL) was added and the aqueous layer was extracted with EtOAC (2×200 mL). The organic extracts were combined, dried over Na2SO4, filtered, and solvent was removed in vacuo. The resulting crude material was reconstituted in MeOH (1.0 mL) and purified by HPLC. The fractions were collected and stripped to dryness via rotary evaporation to yield the title compound. [M+H] calc'd for C12H21BN2O2, 237; found 237.

1. temperatureAfter cooling to RT
2. extractionthe aqueous layer was extracted with EtOAC (2×200 mL)
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customsolvent was removed in vacuo
6. custompurified by HPLC
7. customThe fractions were collected
8. customstripped to dryness via rotary evaporation