Ethanol → HCID 131716791, compound

HRID 5162Notes

Reaction equation

HRID 5162 reaction equation
C([O-])(=O)C.[Na+:5].C(O)C.[CH3:9][S:10][CH2:11][C:12]1[CH2:13][S:14][C@@H:15]2[CH:22]([NH:23][C:24](=[O:34])[C:25]([C:28]3[N:29]=[C:30]([NH2:33])[S:31][CH:32]=3)=[N:26][OH:27])[C:21](=[O:35])[N:16]2[C:17]=1[C:18]([OH:20])=[O:19]>CN(C)C=O>[CH3:9][S:10][CH2:11][C:12]1[CH2:13][S:14][C@@H:15]2[CH:22]([NH:23][C:24](=[O:34])[C:25]([C:28]3[N:29]=[C:30]([NH2:33])[S:31][CH:32]=3)=[N:26][OH:27])[C:21](=[O:35])[N:16]2[C:17]=1[C:18]([O-:20])=[O:19].[Na+:5]

Participants

5

Reactant 3

HCID 702EthanolHCID 517045Sodium AcetateHCID 131716792HCID 131716792, compound

Product 1

HCID 131716791HCID 131716791, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3.5 ml of a methanolic solution of sodium acetate and 30 ml of ethanol were added to a solution of 1 g of the syn isomer of 3-methylthiomethyl-7-[2-(2-amino-4-thiazolyl)-2-hydroxyimino-acetamido]-ceph-3-eme-4-carboxylic acid in 2 ml of dimethylformamide and the mixture was vacuum filtered. The product was rinsed with ethanol and then with ether to obtain 0.804 g of syn isomer of sodium 3-methylthiomethyl-7-[2-(2-amino-4-thiazolyl)-2-hydroxyimino-acetamido]-ceph-3-eme-4-carboxylate.

Workup

  1. filtrationfiltered
  2. washThe product was rinsed with ethanol

Sources & evidence

ORD record
ord-15135c6a32ce4d6eb19033f97ae48811
Source dataset
uspto-grants-1993_09
Patent number
US05243043

Reaction notes

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