反应详情

温度

10 °C

4-Bromobenzene carboximidate (6.0 g, 0.0263 mol) and triethyl amine (3.0 g, 0.0297 mol) is dissolved in toluene (15 ml). It is then cooled to 10° C. 1-naphthoyl chloride (5.0 g, 0.0263 mol) in toluene (10 ml) is added slowly to the reaction mixture over a period of 15 minutes under a nitrogen atmosphere. The reaction mixture is then stirred for 10 hours at 25° C. It is then filtered to remove the triethyl amine hydrochloride salt and the filtrate is concentrated to obtain a yellowish solid, which is washed with hexane (20 ml) and methanol (10 ml) respectively to obtain the pure desired product (Yield=7.5 g (75%)).

1. filtrationIt is then filtered
2. customto remove the triethyl amine hydrochloride salt
3. concentrationthe filtrate is concentrated
4. customto obtain a yellowish solid, which
5. washis washed with hexane (20 ml) and methanol (10 ml) respectively