Hydrochloric Acid → HCID 90408220, compound

HRID 516592Notes

Reaction equation

HRID 516592 reaction equation
[NH2:1][C:2]1[C:7]([CH3:8])=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[C:11]([F:19])[CH:10]=2)[N:5]=[C:4]([C:20]([O:22]C)=[O:21])[C:3]=1[Cl:24].[OH-].[Na+].Cl>CO>[NH2:1][C:2]1[C:7]([CH3:8])=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:16])[F:18])=[C:11]([F:19])[CH:10]=2)[N:5]=[C:4]([C:20]([OH:22])=[O:21])[C:3]=1[Cl:24]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 90409419HCID 90409419, compound

Product 1

HCID 90408220HCID 90408220, compoundYield 59.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To methyl 4-amino-3-chloro-6-(3-fluoro-4-(trifluoromethyl)phenyl)-5-methylpicolinate (0.35 g, 0.96 mmol) in methanol (6.4 mL) was added 2 N NaOH (1.93 mL, 3.9 mmol), and the reaction was stirred at room temperature for 18 h. The solution was acidified with 2 N HCl and the precipitate was vacuum filtered to afford the title compound as a white powder (199 mg, 59%).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-cad9b973bca14cc0966abba8484c36e8
Source dataset
uspto-grants-2015_08
Patent number
US09113629B2

Reaction notes

Loading…