反应详情

A solution of intermediate D1 (3.0 g, 11.7 mmol) and N-bromosuccinimide (2.09 g, 11.7 mmol) in DCM (100 ml) was stirred at room temperature for 1 hour. The solvent was evaporated in vacuo and the crude residue was purified by column chromatography (silica gel; DCM as eluent). The desired fractions were collected and evaporated in vacuo yielding D33 (3.56 g, 91%).

1. customThe solvent was evaporated in vacuo
2. customthe crude residue was purified by column chromatography (silica gel; DCM as eluent)
3. customThe desired fractions were collected
4. customevaporated in vacuo
5. customyielding D33 (3.56 g, 91%)