HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 4-Benzyloxy-3-bromo-1-cyclopropylmethyl-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-(Benzyloxy)-1-(cyclopropylmethyl)pyridin-2(1H)-one | HCID 59497099 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Benzyloxy-3-bromo-1-cyclopropylmethyl-1H-pyridin-2-one | HCID 59497089 | — |
Reaction Steps
A solution of intermediate D1 (3.0 g, 11.7 mmol) and N-bromosuccinimide (2.09 g, 11.7 mmol) in DCM (100 ml) was stirred at room temperature for 1 hour. The solvent was evaporated in vacuo and the crude residue was purified by column chromatography (silica gel; DCM as eluent). The desired fractions were collected and evaporated in vacuo yielding D33 (3.56 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09114138B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-3d5ce9cab12941d29abefe9e5b0461db |
| Source note | uspto-grants-2015_08 |