HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-(2-Hydroxy-3-phenoxypropylamino)acetyl)pyrrolidine-2-carbonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | HCID 71612644 | HCID 71612644 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(2-(2-Hydroxy-3-phenoxypropylamino)acetyl)pyrrolidine-2-carbonitrile hydrochloride | HCID 71612643 | — |
Reaction Steps
1-(2-(2-hydroxy-3-phenoxypropylamino)acetyl)pyrrolidine-2-carbonitrile (3.4 g, 11 mmol) was dissolved in ether (10 mL). Then a solution of HCl in dioxane (4M, 3 mL, 12 mmol) was added to the reaction mixture at −20° C., which was warmed to room temperature and stirred for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115082B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-285602dc7e5145b4ac6ca979f15df708 |
| Source note | uspto-grants-2015_08 |