Hydrochloric Acid → 1-(2-(2-Hydroxy-3-phenoxypropylamino)acetyl)pyrrolidine-2-carbonitrile hydrochloride

HRID 516812Notes

Reaction equation

HRID 516812 reaction equation
[OH:1][CH:2]([CH2:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:3][NH:4][CH2:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]#[N:14])=[O:7].[ClH:23].O1CCOCC1>CCOCC>[ClH:23].[OH:1][CH:2]([CH2:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[CH2:3][NH:4][CH2:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]#[N:14])=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71612644HCID 71612644, compound

Product 1

HCID 716126431-(2-(2-Hydroxy-3-phenoxypropylamino)acetyl)pyrrolidine-2-carbonitrile hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-(2-(2-hydroxy-3-phenoxypropylamino)acetyl)pyrrolidine-2-carbonitrile (3.4 g, 11 mmol) was dissolved in ether (10 mL). Then a solution of HCl in dioxane (4M, 3 mL, 12 mmol) was added to the reaction mixture at −20° C., which was warmed to room temperature and stirred for 1 hour.

Sources & evidence

ORD record
ord-285602dc7e5145b4ac6ca979f15df708
Source dataset
uspto-grants-2015_08
Patent number
US09115082B2

Reaction notes

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