反应详情

1-(2-(2-hydroxy-3-phenoxypropylamino)acetyl)pyrrolidine-2-carbonitrile (3.4 g, 11 mmol) was dissolved in ether (10 mL). Then a solution of HCl in dioxane (4M, 3 mL, 12 mmol) was added to the reaction mixture at −20° C., which was warmed to room temperature and stirred for 1 hour.