Sodium Hydroxide → HCID 178525525, compound

HRID 516879Notes

Reaction equation

HRID 516879 reaction equation
[OH-:1].[Na+:2].[CH:3]1([C:8]2[C:9](=[O:21])[O:10][C:11](=[O:20])[C:12]=2[C@H:13]2[CH2:18][CH2:17][C@@H:16]([OH:19])[CH2:15][CH2:14]2)[CH2:7][CH2:6][CH2:5][CH2:4]1>O1CCOCC1>[CH:3]1(/[C:8](=[C:12](\[C@H:13]2[CH2:18][CH2:17][C@@H:16]([OH:19])[CH2:15][CH2:14]2)/[C:11]([O-:10])=[O:20])/[C:9]([O-:21])=[O:1])[CH2:7][CH2:6][CH2:5][CH2:4]1.[Na+:2].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178519222HCID 178519222, compound

Product 1

HCID 178525525HCID 178525525, compoundYield 102.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 1 M NaOH (0.3 ml, 0.30 mmol) was added to a solution of 3-cyclopentyl-4-(cis-4-hydroxycyclohexyl)furan-2,5-dione (40 mg, 0.15 mmol) in 1,4-dioxane (1.0 ml) at room temperature, and the mixture was stirred for 3 hr. The reaction mixture was concentrated, and the residue was dried in vacuo to give the title compound as a colorless solid (50 mg, quantitative).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-6d2038cc89c2486d886415f0edf766e0
Source dataset
uspto-grants-2015_08
Patent number
US09115079B2

Reaction notes

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