反应详情

A 1.0 M tetrabutyl ammonium fluoride solution in THF (0.29 ml, 0.29 mmol) was added dropwise to a solution of dimethyl 2-(4-((tert-butyldimethylsilyl)oxy)benzyl)-3-(cis-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)maleate (55 mg, 0.10 mmol) in THF (1.0 ml) at 0° C., and the mixture was stirred at room temperature for 5 hr. The solvent was removed by distillation under reduced pressure, and the residue was chromatographed on silica gel column (hexane:ethyl acetate=85:15) to give the title compound as a yellow oil (35 mg, yield 80%).

1. customThe solvent was removed by distillation under reduced pressure
2. customthe residue was chromatographed on silica gel column (hexane:ethyl acetate=85:15)