Trifluoroacetic acid → HCID 86730037, compound

HRID 516940Notes

Reaction equation

HRID 516940 reaction equation
[O:1]=[C:2]1[O:6][CH2:5][C@:4]2([CH2:10][CH2:9][C@H:8]([C:11]3[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])=[CH:13][CH:12]=3)[CH2:7]2)[NH:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:1]=[C:2]1[O:6][CH2:5][C@:4]2([CH2:10][CH2:9][C@H:8]([C:11]3[CH:12]=[CH:13][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[CH:15][CH:16]=3)[CH2:7]2)[NH:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86730036HCID 86730036, compound

Product 1

HCID 86730037HCID 86730037, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of tert-butyl 2-(4-((5R,7S)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-7-yl)phenyl)acetate (I-5A, 1 g, 3.02 mmol) in DCM (20 mL) was added TFA (10 mL). After 2 h, the solution was concentrated in vacuo and used as such for the subsequent step without further purification. HPLC retention time=0.65 min (Condition G); LC/MS M+1=276.

Workup

  1. concentrationthe solution was concentrated in vacuo
  2. customwithout further purification

Sources & evidence

ORD record
ord-223bab2389ab4f56adcbbab56a96497d
Source dataset
uspto-grants-2015_08
Patent number
US09115054B2

Reaction notes

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