Potassium Carbonate → 1-Ethynyl-4-(1-isopropoxycyclopropyl)-benzene

HRID 51713Notes

Reaction equation

HRID 51713 reaction equation
[CH:1]([O:4][C:5]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[C:15][Si](C)(C)C)=[CH:10][CH:9]=2)[CH2:7][CH2:6]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:11]1[CH:12]=[CH:13][C:8]([C:5]2([O:4][CH:1]([CH3:3])[CH3:2])[CH2:6][CH2:7]2)=[CH:9][CH:10]=1)#[CH:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568899[4-(1-Isopropoxycyclopropyl)phenylethynyl]-trimethylsilane2×

Product 1

HCID 225688581-Ethynyl-4-(1-isopropoxycyclopropyl)-benzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-isopropoxycyclopropyl)-phenylethynyl]-trimethylsilane (Intermediate 65, 260.0 mg, 0.96 mmol) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (220 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-0bcab813fe974ca8ba0c2166eb2e9a16
Source dataset
uspto-grants-2004_03
Patent number
US06713647B2

Reaction notes

Loading…