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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 517140Generated: October 31, 2026

Cyclooctanol, 1-ethynyl- → HCID 87082498, compound

https://huagongshe.com/reaction/517140

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclooctanol, 1-ethynyl-HCID 123539—
ReactantN-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamideHCID 57608426—
ProductHCID 87082498HCID 87082498—

Reaction Steps

Sonogashira reaction of 25 with 1-ethynyl-cyclooctanol yielded 2,2,2-trifluoro-N-(3-hydroxy-3-(3-(2-(1-hydroxycyclooctyl)ethynyl)phenyl)propyl)acetamide as yellow oil. Yield (0.54 g, 44%). This compound was used without further purification in the next step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09115056B2
Source datasetuspto-grants-2015_08
ORD IDord-a32094e4110444dbbaed1df55d7d39fa
Source noteuspto-grants-2015_08